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APC 366

CAT: 0804-HY-105999-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-105999-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM) . APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma[1][2].
CAS Number
158921-85-8
UNSPSC
12352005
Target
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/apc-366.html
Purity
99.81
Solubility
10 mM in DMSO
Smiles
OC1=C(C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(N)=O)=O)=O)C=CC3=C1C=CC=C3
Molecular Formula
C22H28N6O4
Molecular Weight
440.50
References & Citations
[1]Barrios VE, et al. Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 1998;63 (26) :2295-2303. |[2]Krishna MT, et al. Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma. J Allergy Clin Immunol. 2001;107 (6) :1039-1045.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

1-Hydroxy-2-naphthoyl-Arg-Pro amide
CAS Number158921-85-8
PubChem CID177340
IUPAC Name(2S)-1-[(2S)-5-(diaminomethylideneamino)-2-[(1-hydroxynaphthalene-2-carbonyl)amino]pentanoyl]pyrrolidine-2-carboxamide
Molecular FormulaC22H28N6O4
Molecular Weight440.5
XLogP0.8
Topological Polar Surface Area177
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count32
Formal Charge0
Complexity725
SMILES
C1C[C@H](N(C1)C(=O)[C@H](CCCN=C(N)N)NC(=O)C2=C(C3=CC=CC=C3C=C2)O)C(=O)N
InChI
InChI=1S/C22H28N6O4/c23-19(30)17-8-4-12-28(17)21(32)16(7-3-11-26-22(24)25)27-20(31)15-10-9-13-5-1-2-6-14(13)18(15)29/h1-2,5-6,9-10,16-17,29H,3-4,7-8,11-12H2,(H2,23,30)(H,27,31)(H4,24,25,26)/t16-,17-/m0/s1
InChIKey
SKYWIMYOGAWOMB-IRXDYDNUSA-N
Chemical Structure
2D Structure
2D structure of 1-Hydroxy-2-naphthoyl-Arg-Pro amide
CAS: 158921-85-8
CID: 177340
Formula: C22H28N6O4
MW: 440.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight440.5
XLogP30.8
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass440.21720340
Monoisotopic Mass440.21720340
Topological Polar Surface Area177 Ų
Heavy Atom Count32
Formal Charge0
Complexity725
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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