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APC-6860

CAT: 0804-HY-114015Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114015Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APC-6860 is a trypsin-like serine proteases inhibitor with ki values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has ki values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer[1][2].
CAS Number
154628-42-9
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apc-6860.html
Solubility
10 mM in DMSO
Smiles
N=C(C1=CC2=C(I)C=CC=C2S1)N
Molecular Formula
C9H7IN2S
Molecular Weight
302.13
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7 (4) :299-312.|[2]Klinghofer V, et al. Species specificity of amidine-based urokinase inhibitors. Biochemistry. 2001 Aug 7;40 (31) :9125-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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