Products for Research Use Only
RegisterLogin

Valproic acid (sodium) (2:1)

CAT: 0804-HY-10585BSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10585BSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Valproic acid (VPA) sodium (2:1) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium (2:1) activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium (2:1) is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches[1][2][3][4][5][6][7].
CAS Number
76584-70-8
Product Name Alternative
Sodium Valproate (2:1) ; VPA (sodium) (2:1) ; 2-Propylpentanoic acid (sodium) (2:1)
UNSPSC
12352211
Hazard Statement
H228
Target
Apoptosis; Autophagy; Endogenous Metabolite; HDAC; HIV; Mitophagy; Notch
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/valproic-acid-sodium-2-1.html
Solubility
10 mM in DMSO
Smiles
CCCC(CCC)C([O-])=O.[0.5Na+]
Molecular Formula
C8H15O2.1/2Na
Molecular Weight
154.71
Precautions
P210-P240-P241-P280-P370+P378
References & Citations
[1]Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30 (6) :2999-3005.|[2]Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276 (39) :36734-41.|[3]Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28.|[4]Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31 (8) :740-50.|[5]Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85 (1) :1-10.|[6]Platta CS, et al. Valproic acid induces Notch1 signaling in small cell lung cancer cells. J Surg Res. 2008 Jul;148 (1) :31-7.|[7]Routy JP, et al. Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study. HIV Med. 2012 May;13 (5) :291-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HDAC; HDAC1; HDAC2

Chemical Information

Divalproex Sodium

Valproate semisodium is a mixture of valproic acid and its sodium salt in a 1:1 molar ratio. It is used for the management and treatment of seizure disorders, mania, and prophylactic treatment of migraine headache. It has a role as an antimanic drug, an anticonvulsant and a GABA agent. It contains a valproic acid and a sodium valproate.

CAS Number76584-70-8
PubChem CID23663956
IUPAC Namesodium;2-propylpentanoate;2-propylpentanoic acid
Molecular FormulaC16H31NaO4
Molecular Weight310.40
Topological Polar Surface Area77.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count10
Heavy Atom Count21
Formal Charge0
Complexity192
SMILES
CCCC(CCC)C(=O)O.CCCC(CCC)C(=O)[O-].[Na+]
InChI
InChI=1S/2C8H16O2.Na/c2*1-3-5-7(6-4-2)8(9)10;/h2*7H,3-6H2,1-2H3,(H,9,10);/q;;+1/p-1
InChIKey
MSRILKIQRXUYCT-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of Divalproex Sodium
CAS: 76584-70-8
CID: 23663956
Formula: C16H31NaO4
MW: 310.40
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight310.40
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count10
Exact Mass310.21200375
Monoisotopic Mass310.21200375
Topological Polar Surface Area77.4 Ų
Heavy Atom Count21
Formal Charge0
Complexity192
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-10585A-01Valproic acid (sodium)
HY-10585AR-01Valproic acid (sodium) (Standard)
HY-10585AG-01Valproic acid (sodium) (GMP)
HY-10585S3-01Valproic acid-d4 (sodium)
HY-10585AS-01Valproic acid-d7 (sodium)
HY-10585AS1Valproic acid-d14 (sodium)
HY-33358-01Valproic acid impurity 1
HY-10585-01Valproic acid
HY-10585S4Valproic acid-d4-1
HY-W7000652,4-Diene-valproic acid

Alternative Products

CatalogName
ENZ-CHM367-0005Valproic acid . sodium
S1168-01Valproic Acid sodium
40160004-2Valproic Acid Sodium Salt
1647-200Valproic Acid, Sodium Salt
A4099-10000Valproic acid sodium salt (Sodium valproate)

Popular Products