Products for Research Use Only
RegisterLogin

Valproic acid-d14 (sodium)

CAT: 0804-HY-10585AS1Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10585AS1Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Valproic acid-d14 (sodium) is deuterium labeled Valproic acid (sodium) . Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
Product Name Alternative
Sodium Valproate-d14; VPA-d14 (sodium) ; 2-Propylpentanoic acid-d14 (sodium)
UNSPSC
12352211
Hazard Statement
H302, H361
Target
Autophagy; Endogenous Metabolite; HDAC; HIV; Isotope-Labeled Compounds; Mitophagy; Notch
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; Others; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
96.45
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C(C(O[Na])=O)C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
Molecular Formula
C8HD14NaO2
Molecular Weight
180.28
Precautions
H302, H361
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85 (1) :1-10.|[3]Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31 (8) :740-50.|[4]Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30 (6) :2999-3005.|[5]Platta CS, et al. Valproic acid induces Notch1 signaling in small cell lung cancer cells. J Surg Res. 2008 Jul;148 (1) :31-7.|[6]Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276 (39) :36734-41.|[7]Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-10585A-01Valproic acid (sodium)
HY-10585AR-01Valproic acid (sodium) (Standard)
HY-10585AG-01Valproic acid (sodium) (GMP)
HY-10585S3-01Valproic acid-d4 (sodium)
HY-10585AS-01Valproic acid-d7 (sodium)
HY-10585BValproic acid (sodium) (2:1)
HY-10585-01Valproic acid
HY-N0728S2α-Linolenic acid-d14
HY-W011873SPalmitoleic acid-d14
HY-B0704S-01Azelaic acid-d14

Alternative Products

CatalogName
AR-V06326-01Valproic Acid-d14 Sodium Salt
ENZ-CHM367-0005Valproic acid . sodium
C07578-1gValproic Acid sodium
40160004-2Valproic Acid Sodium Salt
1647-200Valproic Acid, Sodium Salt
A4099-10000Valproic acid sodium salt (Sodium valproate)
RM-V011266-01Valproic Acid-d14

Popular Products