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JLK-6

CAT: 0804-HY-103538Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103538Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor[1].
CAS Number
62252-26-0
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jlk-6.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=CC(N)=CC=C2C(Cl)=C(OC)O1
Molecular Formula
C10H8ClNO3
Molecular Weight
225.63
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
[1]Marine Peuchmaur, et al. Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein. Bioorg Med Chem. 2013 Feb 15;21 (4) :1018-29.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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