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Anxiolytic/nonsedative agent-1

CAT: 0804-HY-103521Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103521Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anxiolytic/nonsedative agent-1 (compound 2b) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo[1].
CAS Number
355022-97-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/anxiolytic-nonsedative-agent-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C1=CC=CC=C1)C)C(C2=CNC3=C2C=C([N+]([O-])=O)C=C3)=O
Molecular Formula
C18H15N3O4
Molecular Weight
337.33
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Taliani S, et al. Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor. J Med Chem. 2009 Jun 25;52 (12) :3723-34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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