SKF83822 (hydrobromide)

CAT: 0804-HY-103411Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-103411Size:1 Each
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Description
SKF83822 hydrobromide is a potent dopamine D1 receptor agonist. SKF83822 hydrobromide activates Gs/olf/adenylyl cyclase (AC) -coupled D1 receptors, but not phospholipase C (PLC) -coupled D1-like receptors[1].
CAS Number
[74115-10-9]
UNSPSC
12352005
Hazard Statement
H301-H400
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/skf83822-hydrobromide.html
Solubility
10 mM in DMSO
Smiles
OC1=C(O)C=C2C(C3=CC=CC(C)=C3)CN(CC=C)CCC2=C1Cl.[H]Br
Molecular Formula
C20H23BrClNO2
Molecular Weight
424.76
Precautions
P264-P270-P273-P330-P391-P405-P501
References & Citations
[1]Mahomi Kuroiwa, et al. Regulation of DARPP-32 phosphorylation by three distinct dopamine D1-like receptor signaling pathways in the neostriatum. J Neurochem. 2008 Nov;107 (4) :1014-26.|[2]Aliya L Frederick, et al. Neurobehavioral phenotyping of G (αq) knockout mice reveals impairments in motor functions and spatial working memory without changes in anxiety or behavioral despair. Front Behav Neurosci. 2012 Jun 19;6:29.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor

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