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Xestospongin C

CAT: 0804-HY-103312Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-103312Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Xestospongin C ((-) -Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca2+ signaling in neuronal and nonneuronal cells[1][2][3].
CAS Number
88903-69-9
Product Name Alternative
(-) -Xestospongin C
UNSPSC
12352005
Target
Apoptosis; Calcium Channel
Type
Natural Products
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/xestospongin-c.html
Purity
99.9
Solubility
DMSO : 4.47 mg/mL (ultrasonic; warming)
Smiles
[H][C@]1([C@](CCCCCC[C@@](CCN2CCC3)([H])O[C@@]2([H])[C@]3([H])CCCCCC4)([H])CCC5)N5CC[C@]4([H])O1
Molecular Formula
C28H50N2O2
Molecular Weight
446.71
References & Citations
[1]Wang ZJ, et al. Xestospongin C, a Reversible IP3 Receptor Antagonist, Alleviates the Cognitive and Pathological Impairments in APP/PS1 Mice of Alzheimer's Disease. J Alzheimers Dis. 2019;72 (4) :1217-1231.|[2]Gafni J, Munsch JA, Lam TH, Catlin MC, Costa LG, Molinski TF, Pessah IN. Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron. 1997 Sep;19 (3) :723-33. doi: 10.1016/s0896-6273 (00) 80384-0. PMID: 9331361.|[3]Castonguay A, et al. Xestospongin C is a potent inhibitor of SERCA at a vertebrate synapse. Cell Calcium. 2002;32 (1) :39-47.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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