Products for Research Use Only
RegisterLogin

Sino-C

CAT: 0804-HY-179526Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-179526Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Sino-C is a Sinomenine derivative with anticancer activity. Sino-C broadly disrupts cholesterol homeostasis by upregulating key genes such as SREBF2 and HMGCS1, leading to intracellular cholesterol accumulation and lipid droplet formation. Sino-C-induced metabolic dysregulation further triggers lipid peroxidation and endoplasmic reticulum (ER) stress, initiating a unique form of hybrid cell death including apoptotic (cleaved PARP) and necrotic-like features. Sino-C thus serves as a useful compound for research in colorectal cancer, lung cancer and breast cancer[1].
UNSPSC
12352005
Target
Apoptosis; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
O=C1C[C@@]2(CCN3C)C4=C(O)C(O)=CC=C4[C@@H](SCC5=CC=C(Cl)C=C5Cl)[C@@]3([H])C2C=C1OC
Molecular Formula
C25H25Cl2NO4S
Molecular Weight
506.44
References & Citations
[1]Zhang YM, et al. Sino-C, a novel sinomenine derivative, induces cell death bya novel sinomenine derivative, induces cell death by disrupting cholesterol homeostasis in colorectal cancer cells. Acta Pharmacol Sin. 2025 Nov 3. doi: 10.1038/s41401-025-01683-8. Epub ahead of print. PMID: 41184618.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-140336-01C-NH-Boc-C-Bis- (C-PEG1-Boc)
HY-138383CHO-C-PEG2-C-CHO
HY-168132Thalidomide-NH-C-C6H10-C-acid
HY-161974Adamantan-C-amide-PEG2-C-Br
HY-W382140-014′-C-Fluoro-2′-C-methyluridine
HY-178831Azacyclohexane-C-piperazine-C (OCH3) 2
HY-161210Thalidomide-azetidine-C-PIP-C-boc
HY-N15713Lucidone C
HY-N6015-01Bacopasaponin C
HY-154843C-Gem

Alternative Products

CatalogName
GTR19273985-01Sino-C
N2146-25BNeuroendocrine Specific Protein C (NSP-C Rtn C Reticulon C)
GTR18404846-01Antibody to C. trachomatis, C. pneumoniae & C. psittaci
Oneq-V334-01C. jejuni and C. coli
053489Cys-C (Cystatin C)
B2011295C-Phycocyanin (C-PC)
sc-514526Spi-C (C-2)
sc-271243C-Fos (C-10)
sc-166088HLA-C (C-8)
sc-48396C-Yes (C-4)

Popular Products