Prostaglandin E2-d4

Prostaglandin E2-d4

• CAS Number: 34210-10-1
• UNSPSC Description: Prostaglandin E2-d4 is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].
• Target Antigen: Endogenous Metabolite; Prostaglandin Receptor
• Type: Isotope-Labeled Compounds
• Related Pathways: GPCR/G Protein;Metabolic Enzyme/Protease
• Field of Research: Cardiovascular Disease; Endocrinology
• Purity: 99.0
• Solubility: 10 mM in DMSO
• Smiles: OC(CC([2H])([2H])C([2H])([2H])/C=C\C[C@@H](C(C1)=O)[C@H]([C@@H]1O)/C=C/[C@@H](O)CCCCC)=O
• Molecular Weight: 356.49
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Chouaib S, et al. The mechanisms of inhibition of human IL 2 production. II. PGE2 induction of suppressor T lymphocytes. J Immunol. 1984 Apr;132(4):1851-7.|[3]Fernandez-Repollet E, et al. In vivo effects of prostaglandin E2 and arachidonic acid on phagocytosis of fluorescent methacrylate microbeads by rat peritoneal macrophages. J Histochem Cytochem. 1982 May;30(5):466-70.|[4]Haylor J, et al. Renal vasodilator activity of prostaglandin E2 in the rat anaesthetized with pentobarbitone. Br J Pharmacol. 1982 May;76(1):131-7.
• Shipping Conditions: Blue Ice
• Storage Conditions: Solution, -20°C, 2 years
• Clinical Information: No Development Reported