Products for Research Use Only
RegisterLogin

TM5441 (sodium)

CAT: 0804-HY-101761ASize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-101761ASize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM. TM5441 induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence[1][2].
CAS Number
2319722-53-5
UNSPSC
12352005
Target
Apoptosis; PAI-1
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tm5441-sodium.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(NC(COCC(NC2=CC=CC(C3=COC=C3)=C2)=O)=O)C(C(O[Na])=O)=C1
Molecular Formula
C21H16ClN2NaO6
Molecular Weight
450.80
References & Citations
[1]Placencio VR, et al. Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity. PLoS One. 2015 Jul 24;10 (7) :e0133786.|[2]Jeong BY, et al. Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model. PLoS One. 2016 Jun 3;11 (6) :e0157012.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-101761-01TM5441
HY-N15194AInostamycin A (sodium)
HY-166084Docosatetraenoate (sodium)
HY-16366ABriciclib (sodium)
HY-150364AFarabursen (sodium)
HY-107943Tyropanoate (sodium)
HY-W009640AMofebutazone (sodium)
HY-22274-01DMPG (sodium)
HY-17474A-01Parecoxib (Sodium)
HY-148089A-01Eplontersen (sodium)

Alternative Products

CatalogName
GTR19232990-01TM5441 sodium
TRC-S937450-25MGTM5441 Sodium Salt-D4
QXB22143-01TM5441
A19369-10TM5441 10mg
A19369-50TM5441 50mg
A19369-25TM5441 25mg
A19369-100TM5441 100mg
A19369-2TM5441 2mg

Popular Products