Products for Research Use Only
RegisterLogin

TM5441

CAT: 0804-HY-101761-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-101761-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence[1][2].
CAS Number
1190221-43-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; PAI-1
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/TM5441.html
Purity
99.08
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(NC(COCC(NC2=CC=CC(C3=COC=C3)=C2)=O)=O)C(C(O)=O)=C1
Molecular Formula
C21H17ClN2O6
Molecular Weight
428.82
Precautions
H302, H315, H319, H335
References & Citations
[1]Placencio VR, et al. Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity. PLoS One. 2015 Jul 24;10 (7) :e0133786.|[2]Jeong BY, et al. Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model. PLoS One. 2016 Jun 3;11 (6) :e0157012.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
QXB22143-01TM5441
A19369-10TM5441 10mg
A19369-50TM5441 50mg
A19369-25TM5441 25mg
GTR19232990-01TM5441 sodium
A19369-100TM5441 100mg
A19369-2TM5441 2mg
A19369-1TM5441 1mg

Popular Products