MK-212

• Description:

  MK-212 (CPP) is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 can stimulate phosphoinositide hydrolysis in cerebral cortex[1].

• Product Name Alternative:

  CPP

• UNSPSC:

  12352005

• Hazard Statement:

  H317-H319

• Target:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/mk-212.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=NC(N2CCNCC2)=CN=C1

• Molecular Formula:

  C8H11ClN4

• Molecular Weight:

  198.65

• Precautions:

  P261-P264-P272-P280-P302+P352-P362+P364-P501

• References & Citations:

  [1]Lee HS, et, al. Effect of the serotonin agonist, MK-212, on body temperature in schizophrenia. Biol Psychiatry. 1992 Mar 1;31 (5) :460-70.|[2]Conn PJ, et, al. Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. J Pharmacol Exp Ther. 1987 Aug;242 (2) :552-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  5-HT1 Receptor; mLAG-3; α-1 microglobulin

• CAS Number:

  [64022-27-1]