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MK-212

CAT: 0804-HY-101324Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101324Size:1 Each
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Description
MK-212 (CPP) is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 can stimulate phosphoinositide hydrolysis in cerebral cortex[1].
CAS Number
64022-27-1
Product Name Alternative
CPP
UNSPSC
12352005
Hazard Statement
H317-H319
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mk-212.html
Solubility
10 mM in DMSO
Smiles
ClC1=NC(N2CCNCC2)=CN=C1
Molecular Formula
C8H11ClN4
Molecular Weight
198.65
Precautions
P261-P264-P272-P280-P302+P352-P362+P364-P501
References & Citations
[1]Lee HS, et, al. Effect of the serotonin agonist, MK-212, on body temperature in schizophrenia. Biol Psychiatry. 1992 Mar 1;31 (5) :460-70.|[2]Conn PJ, et, al. Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. J Pharmacol Exp Ther. 1987 Aug;242 (2) :552-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT1 Receptor; mLAG-3; α-1 microglobulin

Chemical Information

2-Chloro-6-(1-piperazinyl)pyrazine

2-chloro-6-(1-piperazinyl)pyrazine is a N-arylpiperazine.

CAS Number64022-27-1
PubChem CID107992
IUPAC Name2-chloro-6-piperazin-1-ylpyrazine
Molecular FormulaC8H11ClN4
Molecular Weight198.65
XLogP0.5
Topological Polar Surface Area41.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count13
Formal Charge0
Complexity160
SMILES
C1CN(CCN1)C2=CN=CC(=N2)Cl
InChI
InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
InChIKey
CJAWPFJGFFNXQI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Chloro-6-(1-piperazinyl)pyrazine
CAS: 64022-27-1
CID: 107992
Formula: C8H11ClN4
MW: 198.65
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight198.65
XLogP30.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass198.0672241
Monoisotopic Mass198.0672241
Topological Polar Surface Area41.1 Ų
Heavy Atom Count13
Formal Charge0
Complexity160
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
T21466-01MK-212
T22987-01MK 212 hydrochloride
525681MK-212 HCl
A22531-200MK-212 HCl 200mg
A22531-100MK-212 HCl 100mg
525644MK-212 free base
A22531-50MK-212 HCl 50mg
A22531-10MK-212 HCl 10mg
A22531-5MK-212 HCl 5mg
A22531-25MK-212 HCl 25mg

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