5-MCA-NAT

• Description :

  5-MCA-NAT is a melatonin agonist that may target the melatoninMT3 receptor. 5-MCA-NAT can contract the colonic band in a concentration-dependent manner and reduce intraocular pressure (IOP) in glaucomatous monkey eyes, inhibiting the increase in IOP[1][2].

• CAS Number :

  [190277-13-5]

• UNSPSC :

  12352005

• Target :

  Melatonin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/5-mca-nat.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=CC2=C(NC=C2CCNC(C)=O)C=C1)OC

• Molecular Formula :

  C14H17N3O3

• Molecular Weight :

  275.30

• References & Citations :

  [1]Lucchelli A, et al. Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. Br J Pharmacol. 1997 Aug;121 (8) :1775-81.|[2]Serle JB, et al. Effect of 5-MCA-NAT, a putative melatonin MT3 receptor agonist, on intraocular pressure in glaucomatous monkey eyes. J Glaucoma. 2004 Oct;13 (5) :385-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported