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(+) -Dihydrexidine (hydrochloride)

CAT: 0804-HY-101299Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101299Size:1 Each
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Description
(+) -Dihydrexidine hydrochloride ((+) -DAR-0100 hydrochloride) is a dopamine D1 receptor agonist with an EC50 of 72± 21 nM.
CAS Number
158704-02-0
Product Name Alternative
(+) -DAR-0100 (hydrochloride)
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/__addition__-Dihydrexidine_hydrochloride.html
Solubility
10 mM in DMSO
Smiles
OC1=C(O)C=C(CC[C@]2([H])[C@]3([H])C4=C(C=CC=C4)CN2)C3=C1.Cl
Molecular Formula
C17H18ClNO2
Molecular Weight
303.78
References & Citations
[1]Lewis MM, et al. Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitizationdissociates from both receptor occupancy and functional potency. J Pharmacol Exp Ther. 1998 Jul;286 (1) :345-53.|[2]Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262 (1) :383-93.|[3]Kim KS, et al. Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior. J Neurochem. 2008 Oct;107 (1) :105-15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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