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Dihydrexidine

CAT: 0804-HY-101299ASize: 1 EachDry Ice: NoHazardous: No
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Description
Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC50 of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity[1][2][3][4]. Dihydrexidine can stimulate YAP phosphorylation[5].
CAS Number
123039-93-0
Product Name Alternative
DAR-0100
UNSPSC
12352005
Target
Dopamine Receptor; YAP
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dihydrexidine.html
Solubility
10 mM in DMSO
Smiles
OC1=C(O)C=C(CC[C@]2([H])[C@]3([H])C4=C(C=CC=C4)CN2)C3=C1
Molecular Formula
C17H17NO2
Molecular Weight
267.32
References & Citations
[1]Lovenberg TW, et al. Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. Eur J Pharmacol. 1989 Jul 4;166 (1) :111-3.|[2]Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262 (1) :383-93.|[3]Salmi P, et al. Dihydrexidine--the first full dopamine D1 receptor agonist. CNS Drug Rev. 2004 Fall;10 (3) :230-42.|[4]Gleason, S. D., et al. Effects of dopamine D1 receptor agonists in rats trained to discriminate dihydrexidine. Psychopharmacology, 2006;186 (1), 25–31.|[5]Yu FX, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012;150 (4) :780-791.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
D1 Receptor

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