c-Met-IN-1

c-Met-IN-1

• CAS Number: 2084836-84-8
• UNSPSC Description: c-met-IN-1 (compound 16) is a potent and selective c-Met inhibitor, with IC50 of 1.1 nM, with antitumor activity.[1].
• Target Antigen: c-Met/HGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/c-met-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: FC1=CC(NC(C2=CN(C3=C(OC)C=CC=C3)C=N2)=O)=CC=C1OC4=CC=NC5=CC(OCCCN6CCN(C)CC6)=C(OC)C=C54
• Molecular Weight: 640.70
• References & Citations: [1]Wang X, et al. Design, synthesis and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives as selective c-Met inhibitors. Bioorg Med Chem. 2017 Feb 1;25(3):886-896.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported