MBM-17S

• Target:

  MAPK|||Aurora Kinase|||Apoptosis

• Related Pathways:

  MAPK|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Apoptosis

• Bioactivity:

  MBM-17S, a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM, effectively inhibits cancer cell proliferation by inducing cell cycle arrest and apoptosis. It demonstrates antitumor activities without evident toxicity to mice.

• Smiles:

  O=C(CCC(O)=O)O.O=C(C1=C(OCC2=CC=CC=C2)C=C(C3=CN=C4C=C(C5=CN(CCN(C)C)N=C5)C=CN43)C=C1)N.O=C(CCC(O)=O)O

• Molecular Formula:

  C36H40N6O10

• Molecular Weight:

  716.74

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2083621-91-2