(E) -3-AP

CAT: 0804-HY-10082A-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10082A-01Size:10 mg
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Description
(E) -3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis[1][2].
CAS Number
[200933-27-3]
Product Name Alternative
(E) -PAN-811; (E) -NSC# 663249; (E) -OCX191
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e-3-ap.html
Solubility
10 mM in DMSO
Smiles
NC1=CC=CN=C1/C=N/NC(N)=S
Molecular Formula
C7H9N5S
Molecular Weight
195.24
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Finch RA, et al. Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP) : an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv Enzyme Regul. 1999;39:3-12. |[2]Enyedy ÉA , et al. Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation. Dalton Trans. 2020 Dec 8;49 (46) :16887-16902.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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