(E) -3-AP

• Description :

  (E) -3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis[1][2].

• Product Name Alternative :

  (E) -PAN-811; (E) -NSC# 663249; (E) -OCX191

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H320

• Target :

  DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/e-3-ap.html

• Solubility :

  10 mM in DMSO

• Smiles :

  NC1=CC=CN=C1/C=N/NC(N)=S

• Molecular Formula :

  C7H9N5S

• Molecular Weight :

  195.24

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations :

  [1]Finch RA, et al. Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP) : an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv Enzyme Regul. 1999;39:3-12. |[2]Enyedy ÉA , et al. Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation. Dalton Trans. 2020 Dec 8;49 (46) :16887-16902.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [200933-27-3]