(E)-3-AP

(E)-3-AP

• CAS Number: 200933-27-3
• UNSPSC Description: (E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis[1][2].
• Target Antigen: DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/e-3-ap.html
• Solubility: 10 mM in DMSO
• Smiles: NC1=CC=CN=C1/C=N/NC(N)=S
• Molecular Weight: 195.24
• References & Citations: [1]Finch RA, et al. Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv Enzyme Regul. 1999;39:3-12. |[2]Enyedy ÉA ,et al. Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation. Dalton Trans. 2020 Dec 8;49(46):16887-16902.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported