Dofetilide N-oxide

• UNSPSC Description:

  Dofetilide N-oxide (UK-116856) is a metabolite of Dofetilide. Dofetilide is a class III antiarrhythmic agent that blocks potassium channels[1][2].

• Target Antigen:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/dofetilide-n-oxide.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CS(=O)(NC1=CC=C(CC[N+](CCOC2=CC=C(NS(=O)(C)=O)C=C2)(C)[O-])C=C1)=O

• Molecular Weight:

  457.56

• References & Citations:

  [1]Maisch B, et al. Pregnancy and cardiomyopathies. Herz. 2003 May;28(3):196-208.|[2]Snyders, D.J. and A. Chaudhary, High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol Pharmacol, 1996. 49(6): p. 949-55.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  144449-71-8