Dofetilide N-oxide

Dofetilide N-oxide

• CAS Number: 144449-71-8
• UNSPSC Description: Dofetilide N-oxide (UK-116856) is a metabolite of Dofetilide. Dofetilide is a class III antiarrhythmic agent that blocks potassium channels[1][2].
• Target Antigen: Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/dofetilide-n-oxide.html
• Solubility: 10 mM in DMSO
• Smiles: CS(=O)(NC1=CC=C(CC[N+](CCOC2=CC=C(NS(=O)(C)=O)C=C2)(C)[O-])C=C1)=O
• Molecular Weight: 457.56
• References & Citations: [1]Maisch B, et al. Pregnancy and cardiomyopathies. Herz. 2003 May;28(3):196-208.|[2]Snyders, D.J. and A. Chaudhary, High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol Pharmacol, 1996. 49(6): p. 949-55.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported