Dofetilide

• Description :

  Dofetilide (UK 68789), as a class III antiarrhythmic agent, is an orally active, potent and specific IKr blocker. Dofetilide can be used for the research of cardiovascular disease[1][2].

• Product Name Alternative :

  UK 68789

• UNSPSC :

  12352005

• Hazard Statement :

  H360

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/Dofetilide.html

• Purity :

  98.84

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  CS(=O)(NC1=CC=C(CCN(C)CCOC2=CC=C(NS(=O)(C)=O)C=C2)C=C1)=O

• Molecular Formula :

  C19H27N3O5S2

• Molecular Weight :

  441.56

• Precautions :

  H360

• References & Citations :

  [1]Mounsey JP, et al. Cardiovascular drugs. Dofetilide. Circulation. 2000;102 (21) :2665-2670.|[2]Gwilt M, et al. Dofetilide, a new class III antiarrhythmic agent, reduces pacing induced heterogeneity of repolarisation in vivo. Cardiovasc Res. 1992;26 (11) :1102-1108.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [115256-11-6]