T 26c (sodium)

CAT: 0804-HY-100518ASize: 1 EachDry Ice: NoHazardous: No

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Description

T26c sodium is a potent and selective MMP13 inhibitor with IC50 value of 6.9 pM. T26c sodium can inhibit the degradation of bovine nasal septal cartilage explants[1].

CAS Number

869298-22-6

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/t-26c-sodium.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC1=CC(OC)=CC=C1)C(N(C2=C3C(COCC4=CC=C(C(O[Na])=O)C=C4)=CS2)[Na])=NC3=O

Molecular Formula

C24H19N3Na2O6S

Molecular Weight

523.47

References & Citations

[1]Nara H, et al. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site. Bioorg Med Chem. 2014 Oct 1;22 (19) :5487-505.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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T 26c (sodium)

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