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Calcitriol-d3

CAT: 0804-HY-10002S1Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10002S1Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Calcitriol-d3 is the deuterium labeled Calcitriol[1]. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist[2][3][4][5].
CAS Number
128723-16-0
Product Name Alternative
1,25-Dihydroxyvitamin D3-d3
UNSPSC
12352211
Hazard Statement
H300
Target
Endogenous Metabolite; VD/VDR
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])/C(CCC1)=C/C([2H])=C3\C([C@H](C[C@@H](C3)O)O)=C([2H])/[2H]
Molecular Formula
C27H41D3O3
Molecular Weight
419.65
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Wang G, et al. Calcitriol Inhibits Cervical Cancer Cell Proliferation Through Downregulation of HCCR1 Expression. Oncol Res. 2014;22 (5-6) :301-9.|[3]Santos-Martínez N, et al. Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: a potential new therapeutic approach. BMC Cancer. 2014 Mar 2914:230.|[4]Dong J, et al. Calcitriol restores renovascular function in estrogen-deficient rats through downregulation of cyclooxygenase-2 and the thromboxane-prostanoid receptor. Kidney Int. 2013 Jul84 (1) :54-63.|[5]Chou CL, et al. Beneficial effects of calcitriol on hypertension, glucose intolerance, impairment of endothelium-dependent vascular relaxation, and visceral adiposity in fructose-fed hypertensive rats. PLoS One. 2015 Mar 1610 (3) :e0119843.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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