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Calcitriol

CAT: 0804-HY-10002-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10002-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
CAS Number
32222-06-3
Product Name Alternative
1,25-Dihydroxyvitamin D3
UNSPSC
12352211
Hazard Statement
H300+H310+H330, H372
Target
Drug Metabolite; Endogenous Metabolite; VD/VDR
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Calcitriol.html
Purity
99.94
Solubility
DMSO : 110 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C=C1[C@H](C[C@@H](C/C1=C/C=C2[C@]3([C@@](C)([C@H](CC3)[C@@H](CCCC(C)(O)C)C)CCC/2)[H])O)O
Molecular Formula
C27H44O3
Molecular Weight
416.64
Precautions
H300+H310+H330, H372
References & Citations
[1]Wang G, et al. Calcitriol Inhibits Cervical Cancer Cell Proliferation Through Downregulation of HCCR1 Expression. Oncol Res. 2014;22 (5-6) :301-9.|[2]Santos-Martínez N, et al. Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: a potential new therapeutic approach. BMC Cancer. 2014 Mar 29;14:230.|[3]Dong J, et al. Calcitriol restores renovascular function in estrogen-deficient rats through downregulation of cyclooxygenase-2 and the thromboxane-prostanoid receptor. Kidney Int. 2013 Jul;84 (1) :54-63.|[4]Chou CL, et al. Beneficial effects of calcitriol on hypertension, glucose intolerance, impairment of endothelium-dependent vascular relaxation, and visceral adiposity in fructose-fed hypertensive rats. PLoS One. 2015 Mar 16;10 (3) :e0119843.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite

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