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Calpastatin Antibody

CAT: 0013-GTR18082877-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18082877-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Calpastatin is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpastatin, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpastatin co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.
UniProt
P20810
Reactivity
Human
Immunogen
A recombinant full-length human CAST protein was used as the immunogen for this Calpastatin antibody.
Clonality
Monoclonal
Clone
CAST/1550
Conjugation
Unconjugated
Field of Research
Epigenetics
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Calpastatin antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG1, kappa

UniProtKB · P20810

Calpastatin

ICAL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20810
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CAST
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B7Z468, G5E946, G5E9D3, O95360, Q05DE8, Q7Z4K0, Q96D08, Q9H1Z5
Protein keywords

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Disease

Palmoplantar keratoderma

Molecular function

Protease inhibitorThiol protease inhibitor

Technical term

Proteomics identificationReference proteome

Domain

Repeat

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