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Recombinant Bcl6 Antibody

CAT: 0013-GTR18082492-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18082492-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bcl6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. [UniProt]
UniProt
P41182
Reactivity
Human
Immunogen
Amino acids 256-389 were used as the immunogen for the recombinant Bcl6 antibody.
Clonality
Recombinant
Clone
ARBC6-2R
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml, Prediluted IHC only format: incubate for 30 min at RT (1)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant Bcl6 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG1, kappa

UniProtKB · P41182

B-cell lymphoma 6 protein

BCL6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P41182
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BCL6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
BCL-6
EC number
—
Processing
—
Secondary accessions
A7E241, B8PSA7, D3DNV5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingRepressor

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Biological process

ImmunityInflammatory responseTranscriptionTranscription regulation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

Disease

Proto-oncogene

Domain

RepeatZinc-finger

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