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ALDH1 Antibody

CAT: 0013-GTR18082406-02Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18082406-02Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALDH1A1 belongs to the ALDH enzymes, a family of evolutionarily conserved enzymes comprised of 19 isoforms that are localized in the cytoplasm, mitochondria or nucleus. ALDH1 is predominantly expressed in the epithelium of testis, brain, eye, liver, kidney, as well as neural and hematopoietic stem cells. Reportedly, high ALDH1 expression is found in solitary fibrous tumor (SFT) and hemangiopericytoma (HPC), compared to meningiomas and synovial sarcomas. In combination with CD34, ALDH1 may be useful for the differentiation among SFT, HPC, meningioma, and synovial sarcoma.
UniProt
P00352
Reactivity
Human
Immunogen
A human recombinant partial ALDH1A1 protein (AA 315-434) was used as the immunogen for this ALDH1 antibody.
Clonality
Monoclonal
Clone
AHDH1-1
Conjugation
Unconjugated
Field of Research
Metabolism Research
Purification
Protein G affinity chromatography
Dilution
Western blot: 1-2ug/ml, Immunohistochemistry (FFPE) : 0.5-1ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Titering of the ALDH1 antibody may be required for optimal performance.1. FFPE testing requires sections to be boiled in pH 9 10mM Tris with 1mM EDTA for 10-20 minutes, followed by cooling at RT for 20 minutes, prior to staining.
Tested Applications
IHC-P, WB
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG1, kappa

UniProtKB · P00352

Aldehyde dehydrogenase 1A1

AL1A1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P00352
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ALDH1A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.2.1.19, 1.2.1.28, 1.2.1.3, 1.2.1.36
Processing
—
Secondary accessions
O00768, Q5SYR1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Cellular component

Cell projectionCytoplasm

Biological process

Lipid metabolism

Ligand

NADNucleotide-binding

Molecular function

Oxidoreductase

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