CD68 Antibody

CAT: 0013-GTR18082180-02Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18082180-02Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

This antibody recognizes a glycoprotein of 110kDa, which is identified as CD68. It is important for identifying macrophages in tissue sections. It stains macrophages in a wide variety of human tissues, including Kupffer cells and macrophages in the red pulp of the spleen, in lamina propria of the gut, in lung alveoli, and in bone marrow. It reacts with myeloid precursors and peripheral blood granulocytes. It also reacts with plasmacytoid T cells, which are supposed to be of monocyte/macrophage origin. It shows strong granular cytoplasmic staining of chronic and acute myeloid leukemia and also reacts with rare cases of true histiocytic neoplasia. Lymphomas are negative or show few granules.

UniProt

P34810

Reactivity

Human

Immunogen

A portion of amino acids 150-221 from the human protein was used as the immunogen for the CD68 antibody.

Clonality

Monoclonal

Clone

C68/2501

Conjugation

Unconjugated

Field of Research

Immunology & Inflammation

Purification

Protein G affinity chromatography

Dilution

ELISA (order BSA/sodium azide-free format for coating), Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the CD68 antibody should be determined by the researcher.

Tested Applications

ELISA, IHC-P

Host or Source

Mouse

Preservative

0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide

Isotype

Mouse IgG2c, kappa

UniProtKB · P34810

Macrosialin

CD68_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P34810
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CD68
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: B4DVT4, Q53HR6, Q53XI3, Q96BI7

Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneEndosomeLysosomeMembrane

PTM

Disulfide bondGlycoprotein

Technical term

Proteomics identificationReference proteome

Domain

RepeatSignalTransmembraneTransmembrane helix

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