Dauricine (Standard)

CAT: 0804-HY-N0220RSize: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-N0220RSize:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Dauricine (Standard) is the analytical standard of Dauricine. This product is intended for research and analytical applications. Dauricine, a bisbenzylisoquinoline alkaloid in Menispermum dauricum, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose-and time-dependent manner in colon cancer[1].

CAS Number

524-17-4

UNSPSC

12352005

Target

Apoptosis; NF-κB; Oxidative Phosphorylation; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dauricine-standard.html

Smiles

OC1=CC=C(C[C@H]2N(C)CCC3=C2C=C(OC)C(OC)=C3)C=C1OC4=CC=C(C[C@H]5N(C)CCC6=C5C=C(OC)C(OC)=C6)C=C4

Molecular Formula

C38H44N2O6

Molecular Weight

624.77

References & Citations

[1]Yang Z, et al. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. 2010 Oct;225 (1) :266-75.|[2]Chen C, et al. Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease. Front Cell Dev Biol. 2021 Feb 5;8:624339. |[3]Li W, et al. Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation. Food Chem Toxicol. 2018 Nov;121:156-165.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Chemical Information

Dauricine

Dauricine is a bisbenzylisoquinoline alkaloid resulting from the formal oxidative dimerisation of 4-{[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}phenol by attachment of the phenolic oxygen of one molecule to the benzene ring of the second (ortho to the phenolic hydroxy group of the latter). It has a role as a plant metabolite. It is a bisbenzylisoquinoline alkaloid, a member of isoquinolines, a member of phenols, an aromatic ether and a tertiary amino compound.

CAS Number	524-17-4
PubChem CID	73400
IUPAC Name	4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]phenoxy]phenol
Molecular Formula	C38H44N2O6
Molecular Weight	624.8
XLogP	6.7
Topological Polar Surface Area	72.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	10
Heavy Atom Count	46
Formal Charge	0
Complexity	933

SMILES

CN1CCC2=CC(=C(C=C2[C@H]1CC3=CC=C(C=C3)OC4=C(C=CC(=C4)C[C@@H]5C6=CC(=C(C=C6CCN5C)OC)OC)O)OC)OC

InChI

InChI=1S/C38H44N2O6/c1-39-15-13-26-20-35(42-3)37(44-5)22-29(26)31(39)17-24-7-10-28(11-8-24)46-34-19-25(9-12-33(34)41)18-32-30-23-38(45-6)36(43-4)21-27(30)14-16-40(32)2/h7-12,19-23,31-32,41H,13-18H2,1-6H3/t31-,32-/m1/s1

InChIKey

AQASRZOCERRGBL-ROJLCIKYSA-N

Chemical Structure

2D Structure

CAS: 524-17-4

CID: 73400

Formula: C38H44N2O6

MW: 624.8

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	624.8
XLogP3	6.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	10
Exact Mass	624.31993713
Monoisotopic Mass	624.31993713
Topological Polar Surface Area	72.9 Å²
Heavy Atom Count	46
Formal Charge	0
Complexity	933
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-N0220-01	Dauricine
HY-Z8890R	Norneostigmine (Standard)
HY-Z16070R-01	Hydronopol (Standard)
HY-Z0351R	Trimethylsilanol (Standard)
HY-W142467R-01	Tetraglycine (Standard)
HY-W074890R-01	Palmitoylglycine (Standard)
HY-W055872R-01	Erythromycylamine (Standard)
HY-W040672R-01	Ibufenac (Standard)
HY-W028142R-01	Quipazine (Standard)
HY-W019612R	Enheptin (Standard)

Alternative Products

Catalog	Name
T6S0119-01	Dauricine
A14718-50	Dauricine 50mg
A14718-25	Dauricine 25mg
A14718-10	Dauricine 10mg
A14718-500	Dauricine 500mg
A14718-100	Dauricine 100mg
A14718-1	Dauricine 1mg

Dauricine (Standard)

Chemical Information

Related Products

Alternative Products

Popular Products