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Dauricine

CAT: 0804-HY-N0220-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0220-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dauricine, a bisbenzylisoquinoline alkaloid in Menispermum dauricum, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer[1].
CAS Number
524-17-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; NF-κB; Oxidative Phosphorylation
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dauricine.html
Purity
99.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C[C@H]2N(C)CCC3=C2C=C(OC)C(OC)=C3)C=C1OC4=CC=C(C[C@H]5N(C)CCC6=C5C=C(OC)C(OC)=C6)C=C4
Molecular Formula
C38H44N2O6
Molecular Weight
624.77
Precautions
H302, H315, H319, H335
References & Citations
[1]Yang Z, et al. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. 2010 Oct;225 (1) :266-75.|[2]Chen C, et al. Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease. Front Cell Dev Biol. 2021 Feb 5;8:624339. |[3]Li W, et al. Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation. Food Chem Toxicol. 2018 Nov;121:156-165.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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