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Synaptophysin Antibody / SYP

CAT: 0800-V5336SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V5336SAF-100UGSize:100 µg
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Description
This recombinant rabbit monoclonal antibody recognizes a protein of 38kDa that is identified as synaptophysin. It is an N-glycosylated integral membrane protein found in neurons and endocrine cells. Synaptophysin contains four transmembrane domains and may function as a gap junction-like channel. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. Synaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P08247
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 274-313) from the human protein was used as the immunogen for the Synaptophysin antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
SYP/7976R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the Synaptophysin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Synaptophysin antibody is available for research use only.
Storage Conditions
Aliquot the Synaptophysin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Synaptophysin antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
IHC staining of FFPE human adrenal tissue with Synaptophysin antibody (clone SYP/7976R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P08247

Synaptophysin

SYPH_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08247
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SYP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R7L6, B7Z359, Q6P2F7
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

Calcium

Cellular component

Cytoplasmic vesicleMembraneSynapseSynaptosome

Disease

Disease variantIntellectual disability

PTM

GlycoproteinPhosphoproteinUbl conjugation

Technical term

Proteomics identificationReference proteome

Domain

RepeatTransmembraneTransmembrane helix

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