SDHA Antibody

CAT: 0800-V5083-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V5083-20UGSize:20 µg
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Description
In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P31040
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 450-650) from the human protein was used as the immunogen for the SDHA antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
SDHA/7493
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the SDHA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This SDHA antibody is available for research use only.
Storage Conditions
Aliquot the SDHA antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the SDHA antibody should be determined by the researcher.
Location
Cytoplasm (Mitochondria)
Image Legend
IHC staining of FFPE human kidney tissue with SDHA antibody (clone SDHA/7493) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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