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SDHB Antibody

CAT: 0800-V8073-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8073-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function.Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation.Antibody to SDHB is helpful in the identification of phaeochromocytomas, paragangliomas and GIST.
CAS Number
9007-83-4
Specifications
Western blot: 2-4 µg/mL
UniProt
P21912
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 165-273) were used as the immunogen for this SDHB antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
SDHB/2382
Applications
WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the SDHB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This SDHB antibody is available for research use only.
Storage Conditions
Store the SDHB antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the SDHB antibody should be determined by the researcher.
Image Legend
Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using SDHB antibody (clone SDHB/2382) . These results demonstrate the foremost specificity of the SDHB/2382 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
Product Datasheet
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