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Transferrin Antibody

CAT: 0800-V4960-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V4960-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Iron (Fe) is a tightly metabolically controlled mineral and growth factor present in all living cells. Iron not bound in erythrocyte hemoglobin is transported by transferrin (Tf), the iron transport protein of vertebrate serum. The transferrin protein contains two homologous domains, each of which contain an Fe-binding site. The majority of transferrin is synthesized in the liver and secreted into the blood, but it is also produced in lower amounts in testis and brain as well as in oligodendrocytes, where transferrin is an early marker of oligodendrocyte differentiation. From the blood, transferrin is internalized by erythroblasts and reticulocytes upon binding the transferrin receptor (TfR), also designated CD71, through a system of coated pits and vesicles. After Fe release, transferrin is returned to the extracellular medium, where it can be reused. Defects in the transferrin gene results in atransferrinemia, a rare autosomal recessive disorder characterized by microcytic anemia and iron loading.
CAS Number
9007-83-4
Specifications
ELISA: 2-4 µg/mL for coating (order BSA-free format), Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P02787
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 311-445) from the human protein was used as the immunogen for the Transferrin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
TF/4797
Applications
ELISA, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Transferrin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Transferrin antibody is available for research use only.
Storage Conditions
Aliquot the Transferrin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Transferrin antibody should be determined by the researcher.
Location
Secreted
Image Legend
IHC staining of FFPE human hepatocellular carcinoma tissue with Transferrin antibody (clone TF/4797) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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