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ACTH Antibody / Synacthen

CAT: 0800-V4894-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V4894-100UGSize:100 µg
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Description
ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to Synacthen (aa1-24 of ACTH) ; does not react with CLIP (aa17-39 of ACTH) . POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs) . It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P01189
Host
Rabbit
Reactivity
Human
Immunogen
The N-terminal portion of the human protein was used as the immunogen for the ACTH antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
CLIP/7197R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the ACTH antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ACTH antibody is available for research use only.
Storage Conditions
Aliquot the ACTH antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the ACTH antibody should be determined by the researcher.
Location
Cytoplasm, Secreted
Image Legend
IHC staining of FFPE human pituitary gland tissue with ACTH antibody (clone CLIP/7197R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P01189

Pro-opiomelanocortin

COLI_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01189
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POMC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
POMC
EC number
—
Processing
Precursor
Secondary accessions
P78442, Q53T23, Q9UD39, Q9UD40
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationAmidationCleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoprotein

Molecular function

EndorphinHormone

Disease

Obesity

Cellular component

Secreted

Domain

Signal

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