ACTH Antibody

CAT: 0800-V3212-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V3212-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ACTH (or Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to CLIP (aa 25-39) and does not react with Synacthen (aa 1-24) . POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs) . It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
CAS Number
9007-83-4
Specifications
ELISA (order BSA/sodium azide-free format for coating)
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 25-39 (NGAEDESAEAFPLEF) of Adrenocorticotropic hormone (CLIP sequence) were used as the immunogen for this ACTH antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CLIP/1418
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the ACTH antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This ACTH antibody is available for research use only.
Storage Conditions
Store the ACTH antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the ACTH antibody to be titered up or down for optimal performance.
Location
Cytoplasmic
Image Legend
SDS-PAGE Analysis of Purified, BSA-Free ACTH Antibody (clone CLIP/1418) . Confirmation of Integrity and Purity of the Antibody.
Product Datasheet
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