GCLM Antibody / Glutamate-Cysteine Ligase Regulatory Subunit
CAT:
800-V4661-100UG
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No




GCLM Antibody / Glutamate-Cysteine Ligase Regulatory Subunit
- Description: g-glutamylcysteine synthetase (g-GCS) is the rate limiting enzyme for glutathione (L-g-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. g-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. The human g-GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human g-GCS gene encoding the regulatory subunit maps to chromosome 1p22.1. The two subunits of g-GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond.
- UniProt: P48507
- Host: Mouse
- Immunogen: Recombinant full-length human GLCLR protein was used as the immunogen for the GCLM antibody.
- Clonality: Monoclonal
- Isotype: IgG2a κ
- Applications: IHC-P
- Format: Purified
- Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
- Reconstitution: Aliquot the GLCLR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
- Limitations: This GLCLR antibody is available for research use only.