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CLEC7A Antibody / Dectin 1

CAT: 0800-RQ7430Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ7430Size:100 µg
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Description
C-type lectin domain family 7 member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene. This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q9BXN2
Host
Rabbit
Reactivity
Human
Immunogen
E. coli-derived recombinant human protein (amino acids M1-C233) was used as the immunogen for the CLEC7A antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the CLEC7A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CLEC7A antibody is available for research use only.
Storage Conditions
After reconstitution, the CLEC7A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CLEC7A antibody should be determined by the researcher.
Image Legend
Flow cytometry testing of human U937 cells with CLEC7A antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= CLEC7A antibody.

UniProtKB · Q9BXN2

C-type lectin domain family 7 member A

CLC7A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BXN2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CLEC7A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R861, B7Z494, B7Z5A9, B7Z5B9, Q6IPS7, Q96D32, Q96DR9, Q96LD3, Q96PA4, Q96PA5, Q96PA6, Q96PA7, Q96PA8, Q9H1K3
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmMembrane

PTM

Disulfide bondGlycoproteinPhosphoprotein

Biological process

ImmunityInflammatory responseInnate immunity

Ligand

LectinMetal-binding

Technical term

Proteomics identificationReference proteome

Molecular function

Receptor

Domain

Signal-anchorTransmembraneTransmembrane helix
Product Datasheet
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