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Nos2 Antibody / iNos

CAT: 0800-RQ7239Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ7239Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene. Nitric oxide (NO) is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter; it is implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. Three different NOS isoforms have been identified which fall into two distinct types, constitutive and inducible. The inducible NOS (iNOS) isoform is expressed in a variety of cell types and tissues in response to inflammatory agents and cytokines. The human iNOS (NOS2) gene is approximately 37 kb in length and consists of 26 exons and 25 introns. NOS2-derived NO is a prerequisite for cytokine signaling and function in innate immunity.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P29477
Host
Rabbit
Reactivity
Mouse
Immunogen
Recombinant mouse protein (amino acids I40-L1099) was used as the immunogen for the Nos2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the Nos2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Nos2 antibody is available for research use only.
Storage Conditions
After reconstitution, the Nos2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Nos2 antibody should be determined by the researcher.
Image Legend
Western blot testing of lysed mouse RAW264.7 cells, with (+) and without (-) LPS stimulation, using Nos2 antibody. Predicted molecular weight ~130 kDa.

UniProtKB · P29477

Nitric oxide synthase, inducible

NOS2_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P29477
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Nos2
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
1.14.13.39
Processing
—
Secondary accessions
O70515, O70516, Q5SXT3, Q6P6A0, Q8R410
Protein keywords

Technical term

3D-structureDirect protein sequencingReference proteome

Molecular function

Calmodulin-bindingOxidoreductase

Cellular component

Cytoplasm

Ligand

FADFlavoproteinFMNHemeIronMetal-bindingNADPZinc

PTM

PhosphoproteinUbl conjugation
Product Datasheet
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