PLK1/BRD4-IN-3

PLK1/BRD4-IN-3

• CAS Number: 2251709-91-6
• UNSPSC Description: PLK1/BRD4-IN-3 (Compound 21) is a selective dual inhibitor for bromodomain 4 (BRD4) and polo-like kinase 1 (PLK1). PLK1/BRD4-IN-3 inhibits BRD4-BD1, PLK1 and BRDT-BD1, with IC50s of 0.059, 0.127 and 0.245 μM, respectively[1].
• Target Antigen: Epigenetic Reader Domain; Polo-like Kinase (PLK)
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/plk1-brd4-in-3.html
• Solubility: DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C1[C@H](C)N(C2CCCC2)C3=NC(NC4=CC=C(C(NC5CCN(C)CC5)=O)C=C4OC6CCCC6)=NC=C3N1C
• Molecular Weight: 561.72
• References & Citations: [1]Liu S, et al., Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors. J Med Chem. 2018 Sep 13;61(17):7785-7795.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported