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CBR-5884

CAT: 0804-HY-100012-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100012-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis[1].
CAS Number
681159-27-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Phosphoglycerate Dehydrogenase (PHGDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CBR-5884.html
Concentration
10mM
Purity
99.02
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)C(SC#N)=C(NC(C2=CC=CO2)=O)S1)OCC
Molecular Formula
C14H12N2O4S2
Molecular Weight
336.39
Precautions
H315, H319, H335
References & Citations
[1]Edouard Mullarky et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers Proc Natl Acad Sci U S A, 2016 Feb 16, 113 (7) :1778-83.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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