MEDI-5884

• Description:

  MEDI-5884 is a humanized IgG4Pκ neutralizing monoclonal antibody targeting Endothelial lipase (EL) . MEDI-5884 inhibits EL and increases quantity (particularly phosphatidylinositols and cholesteryl esters) and function of high-density lipoproteins (HDL) . MEDI-5884 can be used for cardiovascular disease like coronary artery disease (CAD) research[1].

• Product Name Alternative:

  REG-101

• UNSPSC:

  12352203

• Target:

  ATGL

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• References & Citations:

  [1]Rosenbaum A I, et al. Inhibition of endothelial lipase by MEDI5884 normalizes phosphatidylinositol levels in coronary artery disease patients[J]. bioRxiv, 2024: 2024.05. 30.596497.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Inhibitory Antibodies

• Clinical Information:

  No Development Reported

• CAS Number:

  [2643310-75-0]