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FOLH1 Antibody / PSMA

CAT: 0800-V7505-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7505-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Folate hydrolase 1 (FOLH1), also known as Prostate-specific membrane antigen (PSMA), is a type II transmembrane glycoprotein belonging to the M28 peptidase family. FOLH1 has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q04609
Host
Mouse
Reactivity
Human, Rat, Dog, Cow
Immunogen
A portion of amino acids 232-433 from the human protein was used as the immunogen for this FOLH1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
FOLH1/2363
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the FOLH1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This FOLH1 antibody is available for research use only.
Storage Conditions
Store the FOLH1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic, cell surface
Image Legend
IHC testing of FFPE human prostate cancer with FOLH1 antibody. Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.

UniProtKB · Q04609

Glutamate carboxypeptidase 2

FOLH1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q04609
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FOLH1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.17.21
Processing
—
Secondary accessions
A4UU12, A9CB79, B7Z312, B7Z343, D3DQS5, E9PDX8, O43748, Q16305, Q541A4, Q8TAY3, Q9NP15, Q9NYE2, Q9P1P8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-bindingZinc

Molecular function

CarboxypeptidaseDipeptidaseHydrolaseMetalloproteaseMultifunctional enzymeProtease

Cellular component

Cell membraneCytoplasmMembrane

PTM

GlycoproteinPhosphoprotein

Domain

Signal-anchorTransmembraneTransmembrane helix

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