Products for Research Use Only
RegisterLogin

AP14145 hydrochloride

CAT: 0013-GTR19189156Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19189156Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AP14145 hydrochloride is a potent and selective negative allosteric modulator of SK2 and SK3 channels (IC50 = 1.1 μM), with activity dependent on S508 and A533 residues. It demonstrates antiarrhythmic efficacy by prolonging the atrial effective refractory period in vivo, including in Vernakalant-resistant models of atrial fibrillation.
CAS Number
2387505-59-9
Field of Research
Pharmacology & Drug Discovery
Smiles
Cl.C[C@@H] (Nc1nc2cccc (NC (C) =O) c2[nH]1) c1cccc (c1) C (F) (F) F
Molecular Formula
C18H18ClF3N4O
Molecular Weight
398.81
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

AP14145 hydrochloride
CAS Number2387505-59-9
PubChem CID146018940
IUPAC NameN-[2-[[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]amino]-1H-benzimidazol-4-yl]acetamide;hydrochloride
Molecular FormulaC18H18ClF3N4O
Molecular Weight398.8
Topological Polar Surface Area69.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity501
SMILES
C[C@H](C1=CC(=CC=C1)C(F)(F)F)NC2=NC3=C(N2)C=CC=C3NC(=O)C.Cl
InChI
InChI=1S/C18H17F3N4O.ClH/c1-10(12-5-3-6-13(9-12)18(19,20)21)22-17-24-15-8-4-7-14(16(15)25-17)23-11(2)26;/h3-10H,1-2H3,(H,23,26)(H2,22,24,25);1H/t10-;/m1./s1
InChIKey
KGIUXIYNTCVBST-HNCPQSOCSA-N
Chemical Structure
2D Structure
2D structure of AP14145 hydrochloride
CAS: 2387505-59-9
CID: 146018940
Formula: C18H18ClF3N4O
MW: 398.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight398.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass398.1121234
Monoisotopic Mass398.1121234
Topological Polar Surface Area69.8 Ų
Heavy Atom Count27
Formal Charge0
Complexity501
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19237745-01AP14145
GTR19204496-01(+) -Dihydrexidine hydrochloride
GTR19204415-01Bometolol Hydrochloride
GTR19204390-01Pevonedistat hydrochloride
GTR19204321GSK9311 hydrochloride
GTR19203922-01Biperiden Hydrochloride
GTR19203748Istaroxime hydrochloride
GTR19203656-01Ribociclib hydrochloride
GTR19203489-01Cirazoline hydrochloride
GTR19202941-01Vernakalant Hydrochloride

Alternative Products

CatalogName
MBS5800328AP14145 hydrochloride
HY-120355AAP14145 (hydrochloride)
HY-120355AP14145
300563Ligustrazine Hydrochloride (Chuanxiongzine hydrochloride)
D3190-91GDeoxynojirimycin Hydrochloride (DNJ Hydrochloride)
OR1043462-01Hydrochloride
MBS6103001-01O-Cyclopropylmethyl-hydroxylamine, Hydrochloride (Cyclopropylmethoxyamine, Hydrochloride, Cyclopropylmethoxylamine, Hydrochloride)
C7050-01Cysteamine hydrochloride; 2-AminoeThanethiol Hydrochloride; 2-Aminoethane-1-Thiol Hydrochloride; Mercaptamine Hydrochloride
P9050-45Propargylamine, Hydrochloride (2-Propynylamine, Hydrochloride)
46264200Thiamine hydrochloride (Vitamin B1 hydrochloride)

Popular Products