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SYCM rabbit pAb

CAT: 0855-ES12869-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES12869-01Size:50 µL
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Background
This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. [provided by RefSeq, Mar 2015]
Description
This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. [provided by RefSeq, Mar 2015],
Product Name Alternative
Probable cysteine--tRNA ligase, mitochondrial (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)
UniProt
Q9HA77
Swiss Prot
Q9HA77
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human SYCM AA range: 95-145
Target
SYCM
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Molecular Weight
60kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
60kD
Fragment
IgG
Subcellular Location
Mitochondrion matrix .
Other Product Names
Probable cysteine--tRNA ligase, mitochondrial (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)
Gene ID (Human)
79587

UniProtKB · Q9HA77

Probable cysteine--tRNA ligase, mitochondrial

SYCM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9HA77
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CARS2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
6.1.1.16
Processing
Precursor
Secondary accessions
Q8NI84, Q96IV4
Protein keywords

Molecular function

Aminoacyl-tRNA synthetaseLigase

Ligand

ATP-bindingMetal-bindingNucleotide-bindingZinc

Disease

Disease variantPrimary mitochondrial disease

Cellular component

Mitochondrion

Biological process

Protein biosynthesis

Technical term

Proteomics identificationReference proteome

Domain

Transit peptide

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