5'-Methylthioadenosine

5'-Methylthioadenosine

• CAS Number: 2457-80-9
• UNSPSC Description: 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].
• Target Antigen: Apoptosis; Endogenous Metabolite; Parasite
• Type: Natural Products
• Related Pathways: Anti-infection;Apoptosis;Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Cancer; Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/5_acute_-_Methylthio_adenosine.html
• Solubility: DMF : 2.5 mg/mL (ultrasonic)|DMSO : 50 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic)
• Smiles: NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CSC)O3
• Molecular Weight: 297.34
• References & Citations: [1]Tang Y, et al. 5'-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37(5):1366-1373.|[2]Li Y, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.|[3]Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine. Cancer Res. 2018;78(15):4386-4395.|[4]Yaofeng Li, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported