5'-Methylthioadenosine-d3

5'-Methylthioadenosine-d3

• CAS Number: 174838-38-1
• UNSPSC Description: 5'-Methylthioadenosine-d3 is the deuterium labeled 5'-Methylthioadenosine[1]. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2][3][4].
• Target Antigen: Apoptosis; Endogenous Metabolite; Parasite
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Apoptosis;Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Inflammation/Immunology
• Purity: 99.81
• Solubility: DMF : 2.5 mg/mL (ultrasonic;warming)|DMSO : 50 mg/mL (ultrasonic;warming)
• Smiles: NC1=C2N([C@]3([H])O[C@@H]([C@H]([C@H]3O)O)CSC([2H])([2H])[2H])C=NC2=NC=N1
• Molecular Weight: 300.35
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Tang Y, et al. 5'-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37(5):1366-1373.2018;78(15):4386-4395.|[3]Li Y, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.|[4]Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine. Cancer Res.|[5]Yaofeng Li, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported