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5'-Methylthioadenosine

CAT: 0804-HY-16938-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16938-01Size:25 mg
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Description
5'-Methylthioadenosine (5'- (Methylthio) -5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].
CAS Number
2457-80-9
Product Name Alternative
5'- (Methylthio) -5'-deoxyadenosine; 5'-Deoxy-5'- (methylthio) adenosine; 5'-S-Methyl-5'-thioadenosine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Endogenous Metabolite; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/5_acute_-_Methylthio_adenosine.html
Purity
99.71
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CSC)O3
Molecular Formula
C11H15N5O3S
Molecular Weight
297.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Tang Y, et al. 5'-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37 (5) :1366-1373.|[2]Li Y, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10 (4) :927-936.|[3]Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine. Cancer Res. 2018;78 (15) :4386-4395.|[4]Yaofeng Li, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10 (4) :927-936.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; Microbial Metabolite

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