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Sotorasib-d7

CAT: 0804-HY-114277S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114277S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sotorasib-d7 (AMG-510-d7) is a deuterium-labeled Sotorasib. Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib leads to the regression of KRAS G12C‑mutated locally advanced or metastatic non‑small cell lung cancer (NSCLC)[2][3].
Product Name Alternative
AMG-510-d7
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Ras
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Others
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.90
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C=C)N1C([2H])([2H])[C@H](C([2H])([2H])[2H])N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)C([2H])([2H])C1
Molecular Formula
C30H23D7F2N6O3
Molecular Weight
567.64
References & Citations
[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82 |[2]Wu LL, et al. AMG-510 and cisplatin combination increases antitumor effect in lung adenocarcinoma with mutation of KRAS G12C: a preclinical and translational research. Discov Oncol. 2023 Jun 7;14 (1) :91.|[3]Ryan MB, et al. KRASG12C-independent feedback activation of wild-type RAS constrains KRASG12C inhibitor efficacy. Cell Rep. 2022 Jun 21;39 (12) :110993.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
K-Ras

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