Sotorasib

• Target :

  Kras|||Ras

• Related Pathways :

  MAPK|||GPCR/G Protein

• Purity :

  0.9995

• Bioactivity :

  Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib exhibits inhibitory activity against KRAS G12C mutant tumors.

• Smiles :

  O=C1N=C(C=2C=C(F)C(=NC2N1C=3C(=NC=CC3C)C(C)C)C=4C(F)=CC=CC4O)N5CCN(C(=O)C=C)CC5C

• Molecular Formula :

  C30H30F2N6O3

• Molecular Weight :

  560.594

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2296729-00-3